Ⅰ 紿佽Е緗戠粶鍙樺紓鏄浠涔堟剰鎬
紿佽Е緗戠粶鏄紲炵粡鍏冧箣闂寸殑榪炴帴錛屽畠閫氳繃浼犻掔炵粡淇″彿鏉ュ疄鐜頒俊鎮浼犻掋傜獊瑙︾綉緇滅殑鍙樺紓涓庝笉鍚屼釜浣撲箣闂寸殑鍙樺紓涓鏍鳳紝鏄鎸囦釜浣撲箣闂村熀鍥犵粍涓婄殑宸寮傘傝繖浜涘樊寮傚彲浠ラ氳繃鑷鐒墮夋嫨鏉ョ瓫閫夛紝浠庤屽獎鍝嶇獊瑙︾綉緇滅殑緇撴瀯鍜屽姛鑳姐
紿佽Е緗戠粶鐨勫彉寮傚彲浠ュ獎鍝嶇炵粡鍏冧箣闂寸殑榪炴帴鍜屼俊鍙蜂紶閫掗熷害銆傝繖浜涘彉寮傚寘鎷鍩哄洜紿佸彉銆佸熀鍥犻噸鎺掋佸熀鍥犺漿搴х瓑銆傝繖浜涘彉寮備笉姝㈠獎鍝嶇炵粡鍏冧箣闂寸殑榪炴帴錛岃繕浼氱洿鎺ュ獎鍝嶇炵粡鍏冪殑鍔熻兘鍜岃屼負琛ㄧ幇銆
鐢變簬紿佽Е緗戠粶鐨勫彉寮備笌琛屼負琛ㄧ幇瀵嗗垏鐩稿叧錛屽洜姝ょ爺絀剁獊瑙︾綉緇滃彉寮傚逛簬鐞嗚В琛屼負鍜岀炵粡緋葷粺鐤劇棶鍏鋒湁閲嶈佹剰涔夈傚逛簬浜虹被錛岀獊瑙︾綉緇滅殑鍙樺紓鍙鑳戒細瀵艱嚧浠庤嚜闂鐥囧埌鑴戞崯浼ょ瓑澶氱嶇炵粡緋葷粺闅滅嶃傚洜姝わ紝鐞嗚В鍜屾不鐤楄繖浜涢殰紕嶇殑鍓嶆櫙涓庣獊瑙︾綉緇滃彉寮傜殑娣卞叆鐮旂┒瀵嗗垏鐩稿叧銆
Ⅱ 紲炵粡縐戝﹀熀紜--紲炵粡紿佽Е
鎻縐樼炵粡鏅鴻瘑錛氱數鍖栧︾獊瑙︾殑紲炵橀摼鎺
鍦ㄥぇ鑴戠殑淇℃伅浜ゆ祦緗戠粶涓錛岀炵粡縐戝︾殑鍩虹煶渚挎槸閭ｇ炲囩殑紲炵粡紿佽Е銆傚畠浠鍒嗕負鐢電獊瑙︿笌鍖栧︾獊瑙︼紝涓よ呭傚悓紲炵粡鍏冮棿鐨勬ˉ姊侊紝鍚勮嚜鎵婕旂潃鐙鐗圭殑瑙掕壊銆
鐢電獊瑙︼細鍗蟲椂閫氫俊鐨勯珮閫熼氶亾
鐢電獊瑙﹀傚悓涓搴х洿鎺ヨ繛鎺ョ殑妗ユ侊紝紱誨瓙嫻佸湪鍏墮棿鑷鐢辯┛姊錛屾棤闇浠諱綍濯掍粙銆傚畠浠鐨勯氶亾瀛斿緞瀹芥暈錛屼紶杈撲俊鍙風殑閫熷害榪呮嵎鏃犳瘮錛屽嚑涔庢棤寤惰繜錛屽弻鍚戝悓姝ョ殑鐗規т嬌鍏跺湪紲炵粡鍏冮棿鐨勪氦嫻佷腑璧峰埌浜嗚嚦鍏抽噸瑕佺殑浣滅敤銆
鍖栧︾獊瑙︼細淇″彿浼犻掔殑縐樺瘑淇′嬌
鍖栧︾獊瑙﹀垯鏇翠負澶嶆潅錛岀敱鍓嶈啘銆侀棿闅欏拰鍚庤啘涓夐儴鍒嗘瀯鎴愩傜炵粡閫掕川錛屽備箼閰拌儐紕憋紝灝卞儚淇′嬌涓鏍鳳紝閫氳繃鍙椾綋浼犻掍俊鎮銆傞掕川鐨勭嶇被鍜岀壒鎬у喅瀹氫簡瀹冧滑鐨勯熷害涓庢晥鏋滐紝浠庡揩閫熺殑鍏村嬫т俊鍙峰埌鎱㈤熺殑鎶戝埗鎬ц皟鎺э紝鍏卞悓濉戦犵炵粡鍙嶅簲鐨勫嶆潅鎬с
閲忓瓙鍖栫殑閲婃斁涓庡啀鎽勫彇
浠や漢鎯婂囩殑鏄錛岄掕川鐨勯噴鏀懼苟闈炶繛緇涓嶆柇錛岃屾槸浠ラ噺瀛愬寲鐨勫艦寮忚繘琛岋紝姣忎釜鍥婃場鏈澶氭惡甯﹀嶮涓囧垎瀛怉Ch錛岃凍浠ュ紩鍙戣倢鑲夌殑鐢典綅鍙樺寲銆傜戝﹀禜euser鍜孯eese鐨勭獊鐮存х爺絀舵彮紺轟簡1:1鍥婃場鋙嶅悎涓庨噴鏀劇殑綺劇『鏈哄埗錛岄殢鍚庣殑榪借釜鐮旂┒濡侹atz鐨勫伐浣滐紝璇佹槑浜嗙炵粡閫掕川鐨勯珮鏁堝啀鎽勫彇榪囩▼銆
閽欑誨瓙涓庨噴鏀劇殑鑸炶箞
閽欑誨瓙鏄榪欎釜榪囩▼鐨勮皟棰戣咃紝閫氳繃紱誨瓙閫氶亾鐨勫紑鍚鎴栧叧闂錛岃皟鎺х潃閲婃斁妯″紡銆係NARE錏嬬櫧鐨勫姞鍏ワ紝鐘瑰傝垶韞堜腑鐨勫紩瀵艱咃紝寮曞煎泭娉¤瀺鍚堝苟瑙﹀彂鑶滅殑鍝嶅簲銆
涓村簥瑙嗚掞細紿佽Е澶卞父鐨勫悗鏋
渚嬪傦紝鑲屾棤鍔涚梲灝辨簮浜庣獊瑙﹀墠鑶滅殑寮傚父錛屽獎鍝嶄簡紲炵粡閫掕川鐨勬ｅ父閲婃斁銆傝屽湪紲炵粡閫掕川鍙椾綋鏂歸潰錛屾湁涓ょ嶄富瑕佺被鍨嬶細閰嶄綋闂ㄦ帶閫氶亾鍜孏錏嬬櫧鑰﹁仈鍙椾綋錛屽畠浠閫氳繃鎺у埗紱誨瓙嫻佸姩鍜屽戦犵獊瑙﹀悗鐢典綅錛岀洿鎺ュ獎鍝嶇炵粡鍏冪殑鍙嶅簲銆
紱誨瓙嫻佺殑緇嗗井騫寵
璋鋒皚閰歌兘紲炵粡鍏冪殑鍏村嬫х獊瑙﹀悗鐢典綅錛圗PSC錛夐氳繃Na+鍜孠+鐨勬祦鍔ㄥ幓鏋佸寲鍚庤啘錛岃屾姂鍒舵х獊瑙︼紙IPSC錛夊垯閫氳繃GABA鍜孋I-鐨勬祦鍔ㄤ嬌鍚庤啘瓚呮瀬鍖栵紝榪欎簺寰濡欑殑騫寵鍐沖畾浜嗙炵粡鍏冪殑鏈緇堝弽搴斻
鍦ㄦ煇浜涙儏鍐典笅錛岃兌璐ㄧ粏鑳炰細鍙備笌鍒扮炵粡鍏冪殑鈥滀笁鏂圭獊瑙︹濅腑錛岀壒鍒鏄鍦ㄧ炵粡鑲跨槫妯″瀷涓錛屽畠浠鍙鑳戒笌鑲跨槫緇嗚優褰㈡垚榪炴帴錛屼絾榪欒繕闇瑕佹洿澶氬疄璇佹潵璇佸疄銆
鎺㈢儲涔嬫棶鐨勭粓鐐
鎬葷粨鏈絝狅紝鎴戜滑棰嗙暐浜嗙炵粡紿佽Е鐨勫氭牱鎬у拰澶嶆潅鎬э紝浠庣數紿佽Е鐨勫揩閫熼氫俊鍒板寲瀛︾獊瑙︾殑淇″彿浼犻掞紝浠庣炵粡閫掕川鐨勯噴鏀懼埌鍐嶆憚鍙栫殑璋冩帶錛屾瘡涓涓鐜鑺傞兘緔у瘑鐩歌繛錛屽叡鍚岀淮緋葷潃澶ц剳鐨勪俊鎮澶勭悊鍜岃屼負璋冩帶銆傛繁鍏ョ爺絀惰繖浜涘熀紜錛屾棤鐤戝皢涓烘垜浠鐞嗚В紲炵粡緋葷粺鐨勮繍浣滄満鍒舵墦寮鏂扮殑瑙嗚掋
- 鍏抽敭鐭ヨ瘑鐐癸細鐢電獊瑙︿笌鍖栧︾獊瑙︾殑宸寮
- 鍖栧︾獊瑙︾殑紲炵粡閫掕川璋冩帶浣滅敤
- 閫掕川鍐嶆憚鍙栦笌淇″彿紼蟲佺殑緇存寔
娣卞叆闃呰繪帹鑽愶細Heuser, J E 絳夊叧浜庣獊瑙﹀泭娉￠噴鏀劇殑璁烘枃錛汚ugustine, G J 鍜 R Eckert 鍏充簬紱誨瓙瀵圭炵粡閫掕川閲婃斁褰卞搷鐨勮烘枃錛屽皢甯︿綘鎺㈢儲鏇存繁灞傛＄殑紲炵粡縐戝﹀ゥ縐樸